Blio reader accepts as input a PDF or ePub version of a text and allows the addition of interactive multi-media elements, including video, quizzes and live internet content. It adds an attractive simulation of a page being turned (reminiscent of the iPad iBook application) while allowing annotations and note taking. An interview with its creator and demonstration of the Blio reader is available at CNET.
That medical textbooks would benefit from additional interactive features was obviously anticipated by the developers of Blio Reader. This is evident on their home page where an anatomy text is prominently displayed.